MOTS-c explained: mitochondrial signalling and metabolic resilience
A mitochondria-derived peptide opening new questions in metabolic research.
Research context
MOTS-c is encoded within mitochondrial DNA and is studied for its role in signalling between mitochondria and the nucleus during metabolic stress.
Reading the evidence
Much of the available literature comes from cell and animal models. Findings should be read with attention to study design, sample size and whether results have been independently replicated.
A note on use
Silsila products are presented for laboratory research only. Nothing in this journal is medical advice, and no product is intended for human or veterinary use.
Sources & evidence
Increased expression of the mitochondrial derived peptide, MOTS-c, in skeletal muscle of healthy aging men
Human tissue and plasma measurements describe associations with ageing; they do not show that administering MOTS-c improves human health.
Read original sourceA study indexed in PubMed or hosted on PMC is not NIH or FDA approval. Findings for approved medicines do not establish the safety or effectiveness of Silsila products.